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Drug Resistance in Mycobacterium tuberculosis: Molecular Mechanisms and LaboratorySusceptibility Testing

Publication year: 
Author (s): 
van Helden; Donald, P.R. (eds.)
Publication in: 
Prog Respir Res. Basel, Karger, 2011, vol 40, pp. 128–144

Evidence is accumulating that drug resistance in Mycobacterium tuberculosis
is by no means a homogeneous biological entity. This perception implies limitations of current procedures for in vitro drug susceptibility testing, based on unique but often poorly understood techniques in diagnostic mycobacteriology. The aim of this paper is to briefly review the molecular mechanisms of mycobacterial drug resistance, to critically reflect the principles involved in drug susceptibility testing of M. tuberculosis in the diagnostic laboratory and to discuss possible implications for therapy.