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Mortality among HIV-positive postpartum women with high cd4 cell counts in Zimbabwe.

Publication year: 
2010
Author (s): 
Hargrove, J W; Humprey, J H
Publication details: 
Harare, Wolters Kluwer Health, 2010
Publication in: 
AIDS 2010, 24:000–000
Abstract:

There is increasing evidence that starting HAART at higher CD4 cell counts reduces mortality and delaysdevelopment of AIDS [1]. In a recent analysis [2],
mortality was compared according to CD4 cell count at HAART initiation among adult patients in 18 cohorts in the United States and Europe. In this analysis, deferringHAARTuntil CD4 cell count reached 251–350 cells/ml was associated with a 28% [95% confidence interval (CI) 4–57] higher rate of AIDS and death compared with starting when CD4 cell count was 351–450 cells/ml, but initiating HAART at CD4 cell counts higher than 351–450 cells/ml conferred no significant benefit. The authors concluded that 350 cells/ml should be the minimum
threshold for HAART initiation.