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WHO Manual for the HIV Drug Resistance Testing Using Dried Blood Spot Specimens

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Geneva, WHO, 2012

This manual provides current best practice guidance for laboratory HIVDR testing using
DBS. Because specific reagents, supplies or equipment may not always be available or
affordable in all areas where genotyping is being performed, three alternative protocols are provided. Where possible, evidence from relevant peer-reviewed publications has been
highlighted. Read all sections of the manual before performing any of the laboratory procedures. Pay special attention to the sections on specimen storage and processing, since these procedures might differ from those recommended by other sources for routine analysis of plasma specimens. Specific products or procedures which we deem to be most strongly recommended, based on available evidence, have been marked in the text.