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HIV 1 natural viral suppressors: control of viral replication in the absense of therapy.

Publication year: 
Author (s): 
Sajadi, M; Heredia, A; Redfield, R
Publication details: 
London, Lippicott Williams and Wilkins, 2007
Publication in: 
AIDS 2007, 21:517–528

The objective of this study was to identify and define a cohort of HIV-1-infected individuals with the ability to suppress HIV-1 replication naturally (patients with undetectable viral loads for at least 2 years without antiretroviral drugs). Proviral DNA
ranged from one to 74 copies/106 peripheral blood mononuclear cells, with the mean value lower by 1–2 logs than long-term non-progressors. This ability to control HIV-1 viral replication naturally has led us to refer to them as natural viral suppressors.